New York: Weight loss surgery curbs sugar cupidity by acting on the brain’s payoff system, a new study has found.
The Study found that gastrointestinal bypass surgery is used to treat morbid obesity and diabetes, decrease sugar-seeking behavior in mice by reducing the release of a payoff chemical called dopamine in the brain.
By shedding light on how bariatric surgeries affect brain function, our study could pave the way for the growth of novel, less-invasive interventions, such as drugs that lower sugar cravings by preventing sugar absorption or metabolism upon coming in the gastrointestinal tract.
Bariatric surgeries are more likely to get when patients substantially decrease their caloric intake, and reducing sugary foods is an important part of these behavioural changes.
The study found that positive outcomes are more likely if sugary foods seem less profitable after surgery.
Patients have reported a change in the type of food they prime after weight-loss surgery.
Building on past studies that showed that the brain dopamine payoff system regulates caloric intake as well as findings from his team that alible sensing in the gastrointestinal tract stimulates dopamine release in the dorsal striatum, de Araujo set out to test whether bariatric surgery relies on the same brain circuitry to curb sugary food preference.
They performed surgery in mice to bypass the first part of the small intestine, straight connecting the stomach to a reduce section of the gastrointestinal tract. The same procedure is performed in humans, but no gastric pouch was constructed to limit food intake.
But bypass surgery stop the sweet-seeking spirt, almost as if it stop the sugar addiction from taking hold.
Our findings provide the first evidence for a causal link between striatal dopamine signalling and the outcomes of bariatric interventions.
However, finally we would like to help patients lose weight and reverse their diabetes without going under the knife.