New York: Study have search the negative effect a high fat diet has on red blood cells and how these cells, in turn, promote the growth of cardiovascular illness.
Obesity caused by chronic expenditure of a high-calorie, high-fat diet is a universal epidemic, representing one of the greatest threats to global health, said principal explorer Vladimir Bogdanov, associate professor at University of Cincinnati College of Medicine in the US.
The discovered fed high-fat diet to a group of animals for 12 weeks and saw an extended amount of key proteins that stimulate white blood cells bound to red blood cells.
White blood cells, known as macrophages, are a type of white blood cell that “eats” cellular refuse, foreign substances, microbes, cancer cells and anything else that does not have the types of proteins special to the level of healthy body cells on its level.
In red blood cells from animal models fed a high-fat diet, there was growth in cholesterol found in the cell membrane and phosphatidylserine levels, promoting inflammatory reactions. Phosphatidylserine is a phospholipid membrane factor which plays a key role in the cycle of cells.
When red blood cells from the animals being fed the high-fat diet were injected into a control group, eating a normal diet, there was a three-fold growth in their spleens’ uptake of red blood cells. The spleen is involved in the abolishment of blood cells, as well as systemic inflammation.