Researchers have identified a drug that works to limit the spread of glioblastoma — the most common primary tumour of the brain and central rampant system which is also regarded as one of the most aggressive of all cancers.
It also increases the Impact of a standard-of-care chemotherapy drug called temozolomide (TMZ), and eradiation, to treat glioblastoma.
“We showed that PPF reduced glioblastoma cell statement of TROY, inhibited glioma cell invasion, and made brain cancer cells more vulnerable to TMZ and radiation,” said the study’s senior author Nhan Tran from Translational Genomics Research Institute (Tgen) in Phoenix, US.
Our data suggests that PPF, working in addition with TMZ and radiation, could limit glioblastoma invasion and renovate the clinical outcome for brain tumor patients.
One of the primary treatments for glioblastoma is surgical abolishment of the tumour. However, because of the rampant way glioblastomas invade investment brain tissue, it is impossible to remove all parts of the tumours, and the cancer eventually returns and spreads.
This barrier works to protect the brain from toxins. However, this security system is so emphatic at conservancy the brain that it prevents many life-saving drugs — all but some small molecules — from being able to treat cancer and other diseases of the brain.